After implementation of the opioid restriction law, the number of NSAID users immediately increased, but the difference was not significant (change, 0. Results Among 46 783 NSAID users with 79 089 NSAID prescriptions during the study period, the median age was 47 years (interquartile range, 35-57 years). Analysis was stratified by route of NSAID administration (oral or nonoral). Individuals were classified as NSAID users if they had at least 1 NSAID prescription in a given month. Main Outcomes and Measures The following outcomes were calculated monthly per 1000 plan enrollees: (1) number of NSAID users (2) mean days’ supply of NSAIDs per prescription and (3) mean number of NSAID prescriptions. Participants were enrollees in a single private health plan of a large university and health system employer in Florida from January 2015 to June 2019.Įxposures Prescriptions for NSAIDs, ascertained from pharmacy claims data.
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Objective To evaluate the association between an opioid restriction law in Florida and use of prescription NSAIDs.ĭesign, Setting, and Participants This quality improvement study used interrupted time series analyses accounting for autocorrelation to estimate immediate and trend changes in the prescribing and use of prescription NSAIDs in Florida before and after implementation of a state law limiting opioid prescriptions to a 3-day supply. Assessment of the association between opioid restrictions and alternative treatment options, such as nonsteroidal anti-inflammatory drugs (NSAIDs), is needed to evaluate potential unintended consequences for patients requiring analgesia. Importance Previous research has shown an immediate reduction in new opioid users and use after implementation of the opioid supply restriction laws. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.